Leader of the group Life Sciences and Health: Leen Stougie.

Our research group creates fundamental knowledge and applied solutions in the broad field of life sciences. We promote understanding of how biological processes work in detail. Our interdisciplinary team of computer scientists, mathematicians and theoretical biologists develops new models, theories, and decision support systems in collaboration with experimental biologists and medical experts. We are motivated by applications of our work in practice


Watch our group video to get a glimpse of our activities or click here for more information about our group structure.



Cells’ own contractions stimulate growth orientation

Cells’ own contractions stimulate growth orientation

During the growth of embryos cells align with forces from the surrounding tissue. These forces originate from differences in growth rates, muscle contractions or gravity. Mathematicians at the CWI research centre in Amsterdam now showed for the first time that active cell contractions can accelerate and facilitate this reorientation of cells. Their research was recently published in the leading Biophysical Journal (112).

Cells’ own contractions stimulate growth orientation - Read More…

Current events

LSH Seminar Leen Stougie

  • 2019-02-26T16:00:00+01:00
  • 2019-02-26T17:00:00+01:00
February 26 Tuesday

Start: 2019-02-26 16:00:00+01:00 End: 2019-02-26 17:00:00+01:00


Metabolic Network Analysis and Phylogeny

In this lecture I will sketch two subfields of my research in life sciences, that have otherwise little overlap.

First I will show how optimization and enumeration play a role in metabolic network analysis and that mathematics can help solving these problems. In particular I will consider so-called flux balance analysis. This is research that has been done and is going on in collaboration with Marie-France Sagot and Arne Reimers.

Then I will give you an example of my research in phylogeny. In particular I will show you that reticulation events like horizontal gene transfer (especially in lower order organisms) require us to abolish the generically used pedigree tree model, but instead settle for a phylogenetic network. I will give some examples of results that we obtained within this model. This is research in collaboration with Leo van Iersel and Steven Kelk.


Associated Members



Current projects with external funding

  • 3D dose reconstruction for children with long-term follow-up Toward improved decision making in radiation treatment for children with cancer
  • Enhancing protein-drug binding prediction
  • ICT based Innovations in the Battle against Cancer – Next - Generation Patient -Tailored Brachytherapy Cancer Treatment Planning
  • Improving Childhood Cancer Care when Parents Cannot be There - Reducing Medical Traumatic Stress in Childhood Cancer Patients by Bonding with a Robot Companion
  • Statistical Models for Structural Genetic Variants in the Genome of the Netherlands
  • Fusible Evolutionary Deep Neural Network Mixture Learning from Distributed Data for Robust Medical Image Analysis (FEDMix)
  • Multi-Objective Deformable Image Registration (MODIR) – An Innovative Synergy of Multi-Objective Optimization, Machine Learning, and Biomechanical Modeling for the Registration of Medical Images with (MODIR)

Related partners

  • AMC Medical Research
  • Elekta Limited
  • Nucletron Operations BV
  • Xomnia
  • Academisch Medisch Centrum
  • Biomedical Imaging Group Rotterdam
  • Erasmus Universiteit Rotterdam
  • KiKa
  • Technische Universiteit Delft
  • Universiteit Leiden