Description

Leader of the group Life Sciences and Health: Leen Stougie.

The CWI Life Sciences and Health (LSH) group is a group of computer scientists and mathematicians whose research focus is on the analysis and design of models and algorithms as well as their direct application to important challenges in the LSH domain.

On the application side, our present team of researchers has expertise in, e.g., computational genomics, medical informatics, computational phylogenetics, and biological network analysis. On the methodological side, we come from different backgrounds, e.g., computational intelligence, computational data science, and operations research. Methodologically, we develop new theories, models, algorithms and decision support tools, for problems that arise mostly in collaboration with experimental biologists and medical experts. We actively collaborate in projects with academic hospitals, biological and biochemical research institutes, and industry.

The LSH group participates in the INRIA International team ERABLE.

Seminars: The LSH group organizes a biweekly seminar.

Watch our group video to get a glimpse of our activities or click here for more information about our group structure.

 

News

Instable blood supply may help healthy cells compete with tumor cells

Instable blood supply may help healthy cells compete with tumor cells

Researchers of CWI’s Scientific Computing group have found that instabilities in the blood supply in cancerous tissue can, surprisingly, lead to a less favorable environment for tumor cells. Their findings shed light on the potential negative side effects of current treatments that aim to actually normalize the blood supply in cancerous tissues.

Instable blood supply may help healthy cells compete with tumor cells - Read More…

Comparing medical images better

Comparing medical images better

Together with the radiation oncology department of AMC, Peter Bosman of CWI’s Life Sciences and Health group has been awarded 1.4 million euros for a project in NWO’s Open Technology Programme for the research and development of a new medical image registration method. This project is co-funded by companies Elekta and Xomnia.

Comparing medical images better - Read More…

A puzzle with a million pieces:  assembling viral genomes from sequencing data

A puzzle with a million pieces: assembling viral genomes from sequencing data

Researchers from CWI’s Life Science and Health group have developed a new computational tool, SAVAGE, for reconstructing the genomes of the different virus strains that affect an infected person. SAVAGE makes it possible to reconstruct the different strains – of which there can be plenty in an infected person – even when so called reference genomes are not available

A puzzle with a million pieces: assembling viral genomes from sequencing data - Read More…

Members

Associated Members

Publications

Software

Current projects with external funding

  • Improving Childhood Cancer Care when Parents Cannot be There - Reducing Medical Traumatic Stress in Childhood Cancer Patients by Bonding with a Robot Companion ()
  • Enhancing protein-drug binding prediction
  • ICT based Innovations in the Battle against Cancer – Next - Generation Patient -Tailored Brachytherapy Cancer Treatment Planning
  • Statistical Models for Structural Genetic Variants in the Genome of the Netherlands
  • Deep Learning based genome wide association techniques for uncovering the missing heritability and novel, clinically actionable genetic variants in ALS (DEEP GWAS for ALS)
  • Fusible Evolutionary Deep Neural Network Mixture Learning from Distributed Data for Robust Medical Image Analysis (FEDMix)
  • Multi-Objective Deformable Image Registration (MODIR) – An Innovative Synergy of Multi-Objective Optimization, Machine Learning, and Biomechanical Modeling for the Registration of Medical Images with (MODIR)
  • Networks
  • Pan-genome Graph Algorithms and Data Integration (PANGAIA)

Related partners

  • AMC Medical Research
  • Elekta Limited
  • Nucletron Operations BV
  • Xomnia
  • Academisch Medisch Centrum
  • Biomedical Imaging Group Rotterdam
  • Erasmus Universiteit Rotterdam
  • Geneton S.R.O.
  • Illumina Cambridge
  • Institut Pasteur
  • Stichting ALS
  • Technische Universiteit Delft
  • Univerzita Komenskeho V Bratislave
  • Universiteit Leiden
  • Universitaet Bielefeld
  • Universita' Degli Studi di Milano-Bicocca