Description
Leader of the group Life Sciences and Health: Leen Stougie.
Our research group creates fundamental knowledge and applied solutions in the broad field of life sciences. We promote understanding of how biological processes work in detail. Our interdisciplinary team of computer scientists, mathematicians and theoretical biologists develops new models, theories, and decision support systems in collaboration with experimental biologists and medical experts. We are motivated by applications of our work in practice.
News
CWI PhD student Jasmijn Baaijens wins Best Talk Award at the ISMB-HitSeq conference
Jasmijn Baaijens, PhD student from CWI’s Life Sciences and Health group, has won the Best Talk Award at ISMB-HitSeq, the world's leading conference on high-throughput genomics.
Instable blood supply may help healthy cells compete with tumor cells
Researchers of CWI’s Scientific Computing group have found that instabilities in the blood supply in cancerous tissue can, surprisingly, lead to a less favorable environment for tumor cells. Their findings shed light on the potential negative side effects of current treatments that aim to actually normalize the blood supply in cancerous tissues.
Comparing medical images better
Together with the radiation oncology department of AMC, Peter Bosman of CWI’s Life Sciences and Health group has been awarded 1.4 million euros for a project in NWO’s Open Technology Programme for the research and development of a new medical image registration method. This project is co-funded by companies Elekta and Xomnia.
A puzzle with a million pieces: assembling viral genomes from sequencing data
Researchers from CWI’s Life Science and Health group have developed a new computational tool, SAVAGE, for reconstructing the genomes of the different virus strains that affect an infected person. SAVAGE makes it possible to reconstruct the different strains – of which there can be plenty in an infected person – even when so called reference genomes are not available
Members of Life Sciences and Health
Publications
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van Iersel, L.J.J, Kelk, S.M, Stamoulis, G, Stougie, L, & Boes, O. (2017). On unrooted and root-uncertain variants of several well-known phylogenetic network problems. Algorithmica, 1–30. doi:10.1007/s00453-017-0366-5
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Virgolin, M, Witteveen, C, Alderliesten, T, & Bosman, P.A.N. (2017). Scalable genetic programming by gene-pool optimal mixing and input-space entropy-based building-block learning. In GECCO 2017 - Proceedings of the 2017 Genetic and Evolutionary Computation Conference (pp. 1041–1048). doi:10.1145/3071178.3071287
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Maree, S.C, Alderliesten, T, Thierens, D, & Bosman, P.A.N. (2017). Niching an estimation-of-distribution algorithm by hierarchical Gaussian mixture learning. In GECCO 2017 - Proceedings of the 2017 Genetic and Evolutionary Computation Conference (pp. 713–720). doi:10.1145/3071178.3071283
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Bouter, A, Pirpinia, K, Alderliesten, T, & Bosman, P.A.N. (2017). Spatial redistribution of irregularly-spaced Pareto fronts for more intuitive navigation and solution selection. In GECCO 2017 - Proceedings of the Genetic and Evolutionary Computation Conference Companion (pp. 1697–1704). doi:10.1145/3067695.3082555
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Voorlichting over KWF in de klas voor groepen 7 Petrusschool - Nieuw Volendam - 12-07-2017. (2017). Voorlichting over KWF in de klas voor groepen 7 Petrusschool - Nieuw Volendam - 12-07-2017.
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Drawing the body by numbers. (2017). Drawing the body by numbers. I/O ICT Onderzoek, 14(2), 10–11.
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Bosman, P.A.N. (2017). General chair's welcome. GECCO 2017 - Proceedings of the 2017 Genetic and Evolutionary Computation Conference.
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Onderzoekers ontwikkelen robotvriendje om kinderen met kanker bij te staan - ziekenhuismanagement.nl - 30-06-2017. (2017). Onderzoekers ontwikkelen robotvriendje om kinderen met kanker bij te staan - ziekenhuismanagement.nl - 30-06-2017.
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Pirpinia, K, Bosman, P.A.N, Loo, C.E, Winter-Warnars, G, Janssen, N.N.Y, Scholten, A.N, … Alderliesten, T. (2017). The feasibility of manual parameter tuning for deformable breast MR image registration from a multi-objective optimization perspective. Physics in Medicine and Biology, 62(14), 5723–5743. doi:10.1088/1361-6560/aa6edc
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Blom, J.G, de Turck, K, & Mandjes, M.R.H. (2017). Refined large deviations asymptotics for Markov-modulated infinite-server systems. European Journal of Operational Research, 259(3), 1036–1044. doi:10.1016/j.ejor.2016.10.050
Software
VirtualLeaf: a modeling framework for plant tissue morphogenesis
VirtualLeaf is a computer modeling framework for the simulation of plant tissue morphogenesis, i.e., the biological development of an organism's shape
Current projects with external funding
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3D dose reconstruction for children with long-term follow-up Toward improved decision making in radiation treatment for children with cancer
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Enhancing protein-drug binding prediction
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ICT based Innovations in the Battle against Cancer – Next - Generation Patient -Tailored Brachytherapy Cancer Treatment Planning
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Improving Childhood Cancer Care when Parents Cannot be There - Reducing Medical Traumatic Stress in Childhood Cancer Patients by Bonding with a Robot Companion
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Statistical Models for Structural Genetic Variants in the Genome of the Netherlands
Related partners
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Nucletron Operations BV
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Academisch Medisch Centrum
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Academisch Medisch Centrum
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KiKa
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Technische Universiteit Delft