Description
Leader of the group Life Sciences and Health: Leen Stougie.
Our research group creates fundamental knowledge and applied solutions in the broad field of life sciences. We promote understanding of how biological processes work in detail. Our interdisciplinary team of computer scientists, mathematicians and theoretical biologists develops new models, theories, and decision support systems in collaboration with experimental biologists and medical experts. We are motivated by applications of our work in practice
Watch our group video to get a glimpse of our activities or click here for more information about our group structure.
News
ESTRO-Elekta Brachytherapy Award for Anton Bouter
Anton Bouter of CWI's Life Sciences & Health group has been awarded the ESTRO-Elekta Brachytherapy Award at the European SocieTy for Radiation & Oncology (ESTRO 38) conference in Milan, Italy.
Reinforcing the electricity grid with Evolutionary Algorithms
In our modern daily life, many activities require electricity, for example, the use of domestic appliances, manufacturing, communication, and transportation. It is therefore essential to maintain a reliable supply of electricity to ensure the operation of such activities.
Peter Bosman appointed part-time professor Delft University of Technology
Recently, Peter A.N. Bosman, senior researcher in the CWI Life Sciences and Health (LSH) group, has been appointed part-time professor Evolutionary Algorithms in the department of Software Technology of the faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) of Delft University of Technology.
Joint eScience and Data Science grant for CWI's Peter Bosman and AMC
Recently, a research proposal that is spearheaded by CWI was granted in the Joint eScience and Data Science programme that was organized jointly by the NWO Domain Science and Netherlands eScience Center (NLeSC). In all projects in this programme, researchers collaborate with eScience engineers of the NLeSC.
Members
Associated Members
Publications
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Pirpinia, K, Bosman, P.A.N, Sonke, J.-J, van Herk, M, & Alderliesten, T. (2019). Evolutionary machine learning for multi-objective class solutions in medical deformable image registration. Special Issue: Evolutionary Algorithms in Health Technologies, 12(5). doi:10.3390/a12050099
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Wang, Z, Virgolin, M, Bosman, P.A.N, Balgobind, B.V, Bel, A, & Alderliesten, T. (2019). Automatic radiotherapy plan emulation for 3D dose reconstruction to enable big data analysis for historically treated patients. In Medical Imaging 2019: Imaging Informatics for Healthcare, Research, and Applications. doi:10.1117/12.2512758
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Kelly, M, van Amerongen, J.H.M, Balvert, M, & Craft, D. (2019). Dynamic fluence map sequencing using piecewise linear leaf position functions. Biomedical Physics & Engineering Express, 5(2). doi:10.1088/2057-1976/aaffe7
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Balvert, M, den Hertog, D, & Hoffmann, A.L. (2019). Robust optimization of dose-volume metrics for prostate HDR-brachytherapy incorporating target and OAR volume delineation uncertainties. INFORMS Journal on Computing, 31(1), 100–114. doi:10.1287/ijoc.2018.0815
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Neumann, F, Polyakovskiy, S, Skutella, M, Stougie, L, & Wu, J. (2019). A Fully Polynomial Time Approximation Scheme for Packing While Traveling. In Lecture Notes in Computer Science/Lecture Notes in Artificial Intelligence. doi:10.1007/978-3-030-19759-9_5
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Pirpinia, K, Bosman, P.A.N, Loo, C.E, Russell, N.S, van Herk, M, & Alderliesten, T. (2018). Simplex-based navigation tool for a posteriori selection of the preferred deformable image registration outcome from a set of trade-off solutions obtained with multiobjective optimization for the case of breast MRI. Journal of Medical Imaging, 5(4). doi:10.1117/1.JMI.5.4.045501
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Karamanis, M, Zambrano, D, & Bohte, S.M. (2018). Continuous-time spike-based reinforcement learning for working memory tasks. In Lecture Notes in Computer Science/Lecture Notes in Artificial Intelligence (pp. 250–262). doi:10.1007/978-3-030-01421-6_25
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Dora, S, Pennartz, C, & Bohte, S.M. (2018). A deep predictive coding network for inferring hierarchical causes underlying sensory inputs. In Lecture Notes in Computer Science/Lecture Notes in Artificial Intelligence (pp. 457–467). doi:10.1007/978-3-030-01424-7_45
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Pozzi, I, Nusselder, R.B.P, Zambrano, D, Bohte, S.M, & Iliadis, L. (2018). Gating sensory noise in a spiking subtractive LSTM. In V Kůrková, Y Manolopoulos, B Hammer, & I Maglogiannis (Eds.), Proceedings of Artificial Neural Networks and Machine Learning - ICANN 2018 (pp. 284–293). Springer, Cham. doi:10.1007/978-3-030-01418-6_28
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Engler, M.S, Caron, B, Veen, L, Geerke, D.P, Mark, A.E, & Klau, G.W. (2018). Multiple-choice knapsack for assigning partial atomic charges in drug-like molecules. In L Parida & E Ukkonen (Eds.), Leibniz International Proceedings in Informatics (pp. 16:1–16:13). Schloss Dagstuhl, Germany. doi:10.4230/LIPIcs.WABI.2018.16
Software
VirtualLeaf: a modeling framework for plant tissue morphogenesis
VirtualLeaf is a computer modeling framework for the simulation of plant tissue morphogenesis, i.e., the biological development of an organism's shape
Current projects with external funding
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3D dose reconstruction for children with long-term follow-up Toward improved decision making in radiation treatment for children with cancer
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Enhancing protein-drug binding prediction
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ICT based Innovations in the Battle against Cancer – Next - Generation Patient -Tailored Brachytherapy Cancer Treatment Planning
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Improving Childhood Cancer Care when Parents Cannot be There - Reducing Medical Traumatic Stress in Childhood Cancer Patients by Bonding with a Robot Companion
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Statistical Models for Structural Genetic Variants in the Genome of the Netherlands
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Fusible Evolutionary Deep Neural Network Mixture Learning from Distributed Data for Robust Medical Image Analysis (FEDMix)
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Multi-Objective Deformable Image Registration (MODIR) – An Innovative Synergy of Multi-Objective Optimization, Machine Learning, and Biomechanical Modeling for the Registration of Medical Images with (MODIR)
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Networks
Related partners
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AMC Medical Research
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Elekta Limited
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Nucletron Operations BV
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Xomnia
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Academisch Medisch Centrum
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Biomedical Imaging Group Rotterdam
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Erasmus Universiteit Rotterdam
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KiKa
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Technische Universiteit Delft
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Universiteit Leiden