Description
Leader of the group Life Sciences and Health: Leen Stougie.
The CWI Life Sciences and Health (LSH) group is a group of computer scientists and mathematicians whose research focus is on the analysis and design of models and algorithms as well as their direct application to important challenges in the LSH domain.
On the application side, our present team of researchers has expertise in, e.g., computational genomics, medical informatics, computational phylogenetics, and biological network analysis. On the methodological side, we come from different backgrounds, e.g., computational intelligence, computational data science, and operations research. Methodologically, we develop new theories, models, algorithms and decision support tools, for problems that arise mostly in collaboration with experimental biologists and medical experts. We actively collaborate in projects with academic hospitals, biological and biochemical research institutes, and industry. Click here for more information about our group structure.
The LSH group participates in the INRIA International team ERABLE.
Seminars: The LSH group organizes a biweekly seminar.
Watch our group video to get a glimpse of our activities.
News
Peter Bosman awarded NWO KLEIN grant
Peter Bosman of CWI's Life Sciences & Health group has been awarded a NWO KLEIN grant together with Amsterdam UMC.
Life Sciences and Health group awarded RISE grant
The Life Sciences and Health group have been awarded a Research and Innovation Staff Exchange (RISE) grant from the European Commission.
CWI develops unique method for genome-reconstruction of mutated viruses
Jasmijn Baaijens, PhD student in CWI’s Life Sciences and Health group, has developed a new computational tool that can reconstruct genomes of mutated versions of viruses like HIV, Zika and Ebola
Humies Silver award for Peter Bosman and colleagues
CWI researchers Peter Bosman and Hoang Luong, along with colleagues from Amsterdam UMC, have been awarded the Humies Silver award at the GECCO 2019 conference, for their efforts in the automated generation of treatment plans for prostate cancer using brachytherapy.
Members
Associated Members
Publications
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Nersisyan, L, Nikoghosyan, M, Arakelyan, A, Francioli, L.C, Menelaou, A. (Androniki), Pulit, S.L. (Sara L.), … The Genome of the Netherlands Consortium, . (2019). WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Nature Scientific Reports, 9(1). doi:10.1038/s41598-019-55109-7
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Luong, N.H, Alderliesten, T, Pieters, B.R, Bel, A, Niatsetski, Y, & Bosman, P.A.N. (2019). Fast and insightful bi-objective optimization for prostate cancer treatment planning with high-dose-rate brachytherapy. Applied Soft Computing, 84. doi:10.1016/j.asoc.2019.105681
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Baller, A.C, van Ee, M, Hoogeboom, M, & Stougie, L. (2019). Complexity of inventory routing problems when routing is easy. Networks. doi:10.1002/net.21908
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Abedin, P, Ganguly, A, Pissis, S, & Thankachan, S.V. (2019). Range Shortest Unique Substring queries. In Proceedings of the International Symposium on String Processing and Information Retrieval (pp. 258–266). doi:10.1007/978-3-030-32686-9_18
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Lopez Rincon, A, Martinez-Archundia, M, Martinez-Ruiz, G.U, Schönhuth, A, & Tonda, A. (2019). Automatic discovery of 100-miRNA signature for cancer classification using ensemble feature selection. BMC Bioinformatics, 20(1). doi:10.1186/s12859-019-3050-8
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Janssen, R, Jones, M.E.L, Kelk, S.M, Stamoulis, G, & Wu, T. (2019). Treewidth of display graphs: bounds, brambles and applications. Journal of Graph Algorithms and Applications, 23(4), 715–743. doi:10.7155/jgaa.00508
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Barton, C, Kociumaka, T, Liu, C, Pissis, S, & Radoszewski, J. (2019). Indexing weighted sequences: Neat and efficient. Information and Computation. doi:10.1016/j.ic.2019.104462
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Dushatskiy, A, Alderliesten, T, Mendrik, A, & Bosman, P.A.N. (2019). Convolutional neural network surrogate-assisted GOMEA. In Proceedings of the 2019 Genetic and Evolutionary Computation Conference (pp. 753–761). doi:10.1145/3321707.3321760
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Murakami, Y, van Iersel, L.J.J, Janssen, R, Jones, M.E.L, & Moulton, V. (2019). Reconstructing tree-child networks from reticulate-edge-deleted subnetworks. Bulletin of Mathematical Biology, 81, 3823–3863. doi:10.1007/s11538-019-00641-w
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Charalampopoulos, P, Kociumaka, T, Pissis, S, Radoszewski, J, Rytter, W, Straszyński, J, … Zuba, W. (2019). Circular pattern matching with k mismatches. In Proceedings of Fundamentals of Computation Theory (pp. 213–228). doi:10.1007/978-3-030-25027-0_15
Software
VirtualLeaf: a modeling framework for plant tissue morphogenesis
VirtualLeaf is a computer modeling framework for the simulation of plant tissue morphogenesis, i.e., the biological development of an organism's shape
Current projects with external funding
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Improving Childhood Cancer Care when Parents Cannot be There - Reducing Medical Traumatic Stress in Childhood Cancer Patients by Bonding with a Robot Companion ()
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Enhancing protein-drug binding prediction
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ICT based Innovations in the Battle against Cancer – Next - Generation Patient -Tailored Brachytherapy Cancer Treatment Planning
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Statistical Models for Structural Genetic Variants in the Genome of the Netherlands
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Deep Learning based genome wide association techniques for uncovering the missing heritability and novel, clinically actionable genetic variants in ALS (DEEP GWAS for ALS)
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Fusible Evolutionary Deep Neural Network Mixture Learning from Distributed Data for Robust Medical Image Analysis (FEDMix)
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Multi-Objective Deformable Image Registration (MODIR) – An Innovative Synergy of Multi-Objective Optimization, Machine Learning, and Biomechanical Modeling for the Registration of Medical Images with (MODIR)
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Networks
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Pan-genome Graph Algorithms and Data Integration (PANGAIA)
Related partners
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AMC Medical Research
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Elekta Limited
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Nucletron Operations BV
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Xomnia
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Academisch Medisch Centrum
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Biomedical Imaging Group Rotterdam
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Erasmus Universiteit Rotterdam
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Geneton S.R.O.
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Illumina Cambridge
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Institut Pasteur
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Stichting ALS
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Technische Universiteit Delft
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Univerzita Komenskeho V Bratislave
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Universiteit Leiden
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Universitaet Bielefeld
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Universita' Degli Studi di Milano-Bicocca