Hans de Vries (AMC Amsterdam) and Evgeny Verbitskiy (Philips Research and University of Groningen) give a talk about how algorithms can optimize insulin treatment for diabetes.

Location: CWI, room M279

Type 1 diabetes is a disease of insulin deficiency, and treatment therefore consists of insulin replacement. Insulin needs vary from day to day dependent on exercise and food intake. The subcutaneous route of insulin administration is not physiological and resorption from the subcutis erratic. Therefore, patients with type 1 diabetes have to decide on insulin dosages and manage their disease with imperfect tools. The holy grail of type 1 diabetes is the closed loop; algorithms using is continuous glucose monitors as input, automatically determine the output, i.e. insulin delivery. Progress and problems with respect to the closed loop will be discussed.

Mathematical challenges of tight glycemic control (Evgeny Verbitskiy)

A brief introduction will be given into modeling, prediction, and control of glucose dynamics in humans. Two competing approaches to the development of closed loop algorithms will be discussed, as well as a personal bet on the potential winner.

More about the Life Sciences seminars.